![]() Typical bronchial carcinoids showed higher and more selective uptake of (68)Ga-DOTATATE than of (18)F-FDG. (68)Ga-DOTATATE was superior to (18)F-FDG in discriminating endobronchial tumor from distal collapsed lung (P = 0.02). There was no instance of false-positive uptake of (68)Ga-DOTATATE, but there were 3 sites of (18)F-FDG uptake secondary to inflammation. Typical carcinoids showed significantly higher uptake of (68)Ga-DOTATATE and significantly less uptake of (18)F-FDG than did tumors of higher grade (P = 0.002 and 0.005). Neither case of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia showed uptake of (68)Ga-DOTATATE or (18)F-FDG. All tumors of higher grade showed high uptake of (18)F-FDG (SUV(max) >or= 11.7), but 3 of 5 showed only minimal accumulation of (68)Ga-DOTATATE (SUV(max) = 2.2-2.8). All typical carcinoids showed high uptake of (68)Ga-DOTATATE (maximum standardized uptake value >or= 8.2), but 4 of 11 showed negative or minimal (18)F-FDG uptake (SUV(max) = 1.7-2.9). Of 18 patients, 15 had primary tumors (median size, 2.7 cm range, 0.5-8 cm) and 3 had recurrent tumors. In all cases, the diagnosis was established on histology. The imaging findings of the first 18 consecutive patients (8 men and 10 women) with pulmonary neuroendocrine tumors (11 typical carcinoids, 2 atypical carcinoids, 1 large cell neuroendocrine tumor, 1 small cell neuroendocrine carcinoma, 1 non-small cell lung cancer with neuroendocrine differentiation, and 2 cases of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia) who underwent (68)Ga-DOTATATE and (18)F-FDG PET/CT were reviewed. Are there brochures or other materials I can have? What websites do you recommend?ĭon't hesitate to ask other questions.Our purpose was to compare the performance of (68)Ga-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-d-Phe(1),Tyr(3)-octreotate (DOTATATE), a novel selective somatostatin receptor 2 PET ligand, and (18)F-FDG in the detection of pulmonary neuroendocrine tumors using PET/CT, with correlation of uptake and tumor grade on histology.How often will you see me for follow-up visits?.What self-care steps can help me manage this condition?.What's the most likely cause of my symptoms?.Possible causes of injury to the affected areaįor DISH, some basic questions to ask include:.Key medical information, including other conditions you have as well as the names and doses of all medications, vitamins or supplements you take.Here's some information to help you get ready for your appointment. After an initial evaluation, your doctor might refer you to a specialist such as a rheumatologist, physiatrist, orthopedic surgeon or neurologist. You're likely to start by seeing your family doctor or a general practitioner. Set the heating pad to low to reduce the risk of burns. Use a heating pad on affected areas of your body to reduce pain. Since obesity is associated with DISH, losing weight might help keep the disease from progressing and lower your risk of complications. Achieve and maintain a desirable weight. ![]() Talk with your doctor before starting an exercise program. ![]() Regular aerobic exercise, such as walking or swimming, can increase your endurance, keep your body more nimble and help you cope with DISH. To help you manage pain and stiffness and to halt progression of the disease, try these self-care measures: Surgery might also relieve pressure on the spinal cord caused by DISH. People who have difficulty swallowing due to large bone spurs in the neck might need surgery to remove the bone spurs. Surgery might be needed in rare cases when diffuse idiopathic skeletal hyperostosis causes severe complications. He or she might refer you to a physical therapist for further guidance. Ask your doctor about specific exercises you can do. Exercises might also increase the range of motion in your joints. Physical therapy can reduce the stiffness associated with DISH. More-severe pain can be treated with corticosteroid injections. Your doctor might recommend over-the-counter pain relievers, such as acetaminophen (Tylenol, others) or ibuprofen (Advil, Motrin IB, others). Treatment is also aimed at keeping the condition from worsening and at preventing complications.īecause of the relationship between DISH and conditions such as obesity, insulin resistance and type 2 diabetes, treating those conditions might slow or halt the progression of DISH. While there's no cure for diffuse idiopathic skeletal hyperostosis, you can take steps to reduce pain and stiffness.
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